Vaccine Health & Safety

Let’s get a few details straight

Safety is our first priority

  • Plasmid DNA (pDNA) vaccines do not contain any antimicrobial resistance coding sequence. How? The BPE plasmid is initially located and replicated within the genome of a genetically modified bacterial host and later regenerated through recombination, which removes any requirement for antimicrobial resistance during fermentation.

  • All vaccines are batch tested for any trace contaminants from the fermentation bacteria.

  • All batches are deep sequenced (Oxford Nanopore) to confirm the sequence and ensure there are no contaminating plasmid populations.

  • All vaccines go through stringent animal trials to prove efficacy and safety.

  • The entire BPE plasmid and target sequence is curated to contain minimal homology to the chromosome of the target species, further reducing the risk of chromosomal integration.

  • Bacterial sequences are unable to replicate in the vaccine animal

About DNA vaccine platforms

Plasmid DNA (pDNA) is the basis of our technology.

Plasmids purposely replicate in bacterial cells, but are unable to replicate in Eukaryotic cells (a type of cell found in things like animals, plants, and fungi). This means they cannot continue to grow outside of laboratory settings.

  • pDNA has been shown to rarely integrate into the chromosome of the host, to the point where it is negligible.

  • All pDNA sequences have purposefully been designed to minimize homologous sequences to any Eukaryotic sites, further preventing the integration of plasmid DNA into the chromosome.

  • The vaccine is taken from a pathogen, but expressed alone it is impossible for the sequence to be infectious.

A few quick facts:

  • Every nucleotide in our vaccines are screened and purposefully placed in the plasmid. There are no extra sequences across the entire vaccine.

  • All vaccine and pDNA backbones are designed with regulatory approval in mind.

  • Learn more about the pDNA backbone technology here.